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Owen Nelson
Owen Nelson

Prototype 1 Crack Only Download 14

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prototype 1 crack only download 14

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To make the stent with covered membrane more uniformly adhered to the surface and easily regulate the thickness according to the clinical needs, electrospinning/electrospraying has been regarded as the appropriate means for demonstrating the PDT-chemo stent[18, 19]. The covered stent can be manufactured by several electrospinning methods: post-spinning modification, drug/polymer blends, emulsion electrospinning and core-shell electrospinning[21]. Drug/polymer blends technique could easily mix the drug with polymer directly and form a layer of membrane to achieve sustained drug release. Therefore, in this study, the prototype of PDT-chemo stent was constructed by drug/polymer blends technique via electrospinning and electrospraying dual-processes. The backing layer was electrospun first from PU polymer solution, followed by the electrospraying process from PCL/PEG blends solution with drug loaded. Electrospinning is the process with voltage to extrude polymer solution into fine fibers for the production of fine-fibers-covered stents. In our case, fine fibers could support the superior mechanical properties of the membrane and be introduced as the backing layer for effectively controlling majority of the inner drugs released to the surrounding tissue. During electrospinning, the organic solvent, which could be toxic to cells, will be completely evaporated due to its high volatility[22]. Electrospraying has similar preparation process to electrospinning but is usually used with higher voltage and lower polymer density, which makes the polymer solution more easily broken up into droplets[23, 24]. The concept of electrospraying process was used to increase layer-to-layer adhesion, which could avoid drug-storing layer cracking and separating from backing layer during the stent expending.


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